RCBTB2 Gene Summary [Human]
This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Details
| Type | Protein Coding |
| Official Symbol | RCBTB2 |
| Official Name | RCC1 and BTB domain containing protein 2 [Source:HGNC Symbol;Acc:HGNC:1914] |
| Ensembl ID | ENSG00000136161 |
| Bio databases IDs | |
| Aliases | RCC1 and BTB domain containing protein 2 |
| Synonyms | 2610028E02Rik, 2810420M18Rik, CHC1L, RC/BTB2, RCC1 and BTB domain containing protein 2, RCC1-LIKE G EXCHANGING FACTOR RLG, regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2, RLG |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RCBTB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of chromosome condensation (RCC1) repeat
- Broad-Complex, Tramtrack and Bric a brac
- guanyl-nucleotide exchange factor
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- diabetes mellitus
- neoplastic histiocytosis
- hematologic cancer
- hematological neoplasia
- lymphomagenesis
- prostate cancer
- gastrointestinal neoplasia
- lymphoid cancer
role in cell
- function
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RCBTB2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- acrosomal vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity