GAL3ST4 Gene Summary [Human]
This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GAL3ST4 |
| Official Name | galactose-3-O-sulfotransferase 4 [Source:HGNC Symbol;Acc:HGNC:24145] |
| Ensembl ID | ENSG00000197093 |
| Bio databases IDs | |
| Aliases | galactose-3-O-sulfotransferase 4 |
| Synonyms | 1500031A01Rik, galactose-3-O-sulfotransferase 4, galactose-3-O-sulphotransferase 4, RGD1561105 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GAL3ST4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- galactose 3-O-sulfotransferase
- enzyme
- Galactose-3-O-sulfotransferase
- Sulfotransferase family
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GAL3ST4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein biosynthetic process
- sulfur compound metabolic process
- glycoprotein metabolic process
- cell-cell signaling
- glycolipid biosynthetic process
- oligosaccharide metabolic process
- proteoglycan biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- Golgi cisterna membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- galactose 3-O-sulfotransferase activity
- galactosylceramide sulfotransferase activity
- 3'-phosphoadenosine 5'-phosphosulfate binding
- proteoglycan sulfotransferase activity