B3GNT6 Gene Summary [Human]
The protein encoded by this gene is a beta-1,3-N-acetylglucosaminyltransferase that adds an N-acetylglucosamine moiety to N-acetylgalactosamine-modified serine or threonine. The encoded enzyme is responsible for creating the core 3 structure of O-glycans, which are important components of mucin-type glycoproteins. [provided by RefSeq, Dec 2016]
Details
| Type | Protein Coding |
| Official Symbol | B3GNT6 |
| Official Name | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:24141] |
| Ensembl ID | ENSG00000198488 |
| Bio databases IDs | |
| Aliases | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6, core 3 synthase |
| Synonyms | beta-1,3-Gn-T6, beta3Gn-T6, BGnT-6, C3gnt, Core-3, RGD1310926, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6, UDP-GlcNAc:betaGal β-1,3-N-acetylglucosaminyltransferase 6, β-1,3-Gn-T6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human B3GNT6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase
- galactosyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi region
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human B3GNT6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein biosynthetic process
- protein O-linked glycosylation
- O-glycan processing
- poly-N-acetyllactosamine biosynthetic process
- O-glycan processing, core 3
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- UDP-glycosyltransferase activity
- acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
- UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
- galactosyltransferase activity