STK19 Gene Summary [Human]
This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | STK19 |
| Official Name | serine/threonine kinase 19 [Source:HGNC Symbol;Acc:HGNC:11398] |
| Ensembl ID | ENSG00000204344 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 19 |
| Synonyms | D6S60, D6S60E, G11, HLA-RP1, RP1, serine/threonine kinase 19, STK19, TWH19, winged helix repair factor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- double-stranded DNA binding
- Serine-threonine protein kinase 19
- double-stranded RNA binding
- protein homodimerization
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inguinal hernia
- major depression
- hypothyroidism
- membranous glomerulonephritis
- skin basal cell carcinoma
- basal cell skin cancer
- systemic lupus erythematosus
- sarcoidosis
- schizophrenia
- bullous pemphigoid
regulated by
- chelidonine
- PC-SPES
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Ras protein signal transduction
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein serine/threonine kinase activity