ZRANB1 Gene Summary [Human]
Enables K63-linked polyubiquitin modification-dependent protein binding activity and thiol-dependent deubiquitinase. Involved in several processes, including positive regulation of Wnt signaling pathway; protein deubiquitination; and regulation of cell morphogenesis. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZRANB1 |
| Official Name | zinc finger RANBP2-type containing 1 [Source:HGNC Symbol;Acc:HGNC:18224] |
| Ensembl ID | ENSG00000019995 |
| Bio databases IDs | |
| Aliases | zinc finger RANBP2-type containing 1 |
| Synonyms | 9330160G10Rik, D7Wsu87e, Gm1956, LOC100359837, TRABID, zinc finger, RAN-binding domain containing 1, zinc finger RANBP2-type containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZRANB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin ubiquitin-binding domain
- Zn-finger in Ran binding protein and others
- ubiquitin-specific protease
- enzyme
- protein binding
- Npl4 zinc finger domain
- zinc finger domain
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- experimental autoimmune encephalomyelitis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- lung cancer
- chromosomal instability
role in cell
- expression in
- phosphorylation in
- synthesis in
- number
- growth
- degradation in
- formation
- formation in
- ferroptosis
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZRANB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination involved in ubiquitin-dependent protein catabolic process
- regulation of cell morphogenesis
- cytoskeleton organization
- Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
- cell migration
- protein K29-linked deubiquitination
- protein K63-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- K63-linked polyubiquitin binding
- metal ion binding
- polyubiquitin binding