Stk19 Gene Summary [Mouse]
Predicted to enable double-stranded DNA binding activity and protein homodimerization activity. Predicted to be involved in positive regulation of Ras protein signal transduction and positive regulation of single strand break repair. Predicted to be located in cytoplasm and nuclear speck. Orthologous to human WHR1 (winged helix repair factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stk19 |
| Official Name | serine/threonine kinase 19 [Source:MGI Symbol;Acc:MGI:1860085] |
| Ensembl ID | ENSMUSG00000061207 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 19 |
| Synonyms | D6S60, D6S60E, G11, HLA-RP1, RP1, serine/threonine kinase 19, STK19, TWH19, winged helix repair factor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stk19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- double-stranded DNA binding
- Serine-threonine protein kinase 19
- double-stranded RNA binding
- protein homodimerization
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inguinal hernia
- major depression
- hypothyroidism
- membranous glomerulonephritis
- skin basal cell carcinoma
- basal cell skin cancer
- systemic lupus erythematosus
- sarcoidosis
- schizophrenia
- bullous pemphigoid
regulated by
- chelidonine
- PC-SPES
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stk19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Ras protein signal transduction
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein serine/threonine kinase activity