SPINK9 Gene Summary [Human]
The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | SPINK9 |
| Official Name | serine peptidase inhibitor Kazal type 9 [Source:HGNC Symbol;Acc:HGNC:32951] |
| Ensembl ID | ENSG00000204909 |
| Bio databases IDs | |
| Aliases | serine peptidase inhibitor Kazal type 9 |
| Synonyms | LEKTI2, LOC102547035, serine peptidase inhibitor Kazal type 9, serine protease inhibitor Kazal-type 9-like |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPINK9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- serine protease inhibitor activity
- protein binding
- KAZAL_FS
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPINK9 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding