H1-10
H1-10 Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | H1-10 |
| Official Name | H1.10 linker histone [Source:HGNC Symbol;Acc:HGNC:4722] |
| Ensembl ID | ENSG00000184897 |
| Bio databases IDs | |
| Aliases | H1.10 linker histone |
| Synonyms | Gm461,H1.10,H1.10 linker histone,H1f10,H1FX,H1X,RGD1565596 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- linker histone H1 and H5 family
- H15
- protein binding
Pathways
Biological processes and signaling networks where the H1-10 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TNF
- SLC25A6
- CHD4
- G3BP2
- RPN1
- KLF16
- H2BC12
- FANCD2
- CBX3
- RPA3
disease
regulated by
- lipopolysaccharide
- IL1B
- TGFB1
- AGT
- tetradecanoylphorbol acetate
- SPOP
- ionomycin
- Lmp2a
- SOX4
- doxycycline
regulates
- UGT2B10
- SPINK9
- KNG1
- ALOX15B
- AMTN
- KRT37
role in cell
- expression in
- number
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the H1-10 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chromosome condensation
- nucleosome assembly
- negative regulation of DNA recombination
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- chromosome
- nucleosome
- nucleolus
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- structural constituent of chromatin
- RNA binding
- cadherin binding
- nucleosomal DNA binding
- double-stranded DNA binding