CD177 Gene Summary [Human]
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | CD177 |
| Official Name | CD177 molecule [Source:HGNC Symbol;Acc:HGNC:30072] |
| Ensembl ID | ENSG00000204936 |
| Bio databases IDs | |
| Aliases | CD177 molecule, polycythemia rubra vera 1 |
| Synonyms | BX115698, CD177 molecule, HNA-2a, NB1, NB1 GP, PRV-1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD177 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- TFP_LU_ECD_LYPD4_rpt2_like
- protease binding
- integrin binding
- protein binding
- TFP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic inflammatory myopathy
- breast cancer
- ulcerative colitis
- septic shock
- paroxysmal nocturnal hemoglobinuria
- colorectal cancer
- Crohn disease
- sepsis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- adhesion
- binding
- endocytosis by
- degranulation
- cell-cell adhesion
- transendothelial migration
- extravasation by
- migration by
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Golgi Apparatus
- secretory granule membrane
- tertiary granule membrane
- specific granule membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD177 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- regulation of integrin-mediated signaling pathway
- innate immune response
- neutrophil extravasation
- cell adhesion
- regulation of endocytosis
- leukocyte cell-cell adhesion
- positive regulation of neutrophil degranulation
- cell-cell junction maintenance
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular vesicular exosome
- plasma membrane
- tertiary granule membrane
- specific granule membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium-dependent protein binding
- protease binding
- integrin binding