ITGB2 Gene Summary [Human]
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Details
| Type | Retained Intron |
| Official Symbol | ITGB2 |
| Official Name | integrin subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:6155] |
| Ensembl ID | ENSG00000160255 |
| Bio databases IDs | |
| Aliases | integrin subunit beta 2, complement component 3 receptor 3 and 4 subunit |
| Synonyms | 2E6, beta2 INTEGRINS, CD18, Cr3 beta, Cr3 β, Integrin beta2, integrin subunit beta 2, integrin subunit β 2, Integrin-β 2, LAD, LCAMB, Leucocyte Cell Adhesion Molecule, LFA-1, Lfa-1 beta, LFA1 beta CHAIN, Lfa-1 β, LFA-1 β 2, LFA1 β CHAIN, MAC-1, MF17, MFI7, β 2 integrin, β(2)-integrin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ITGB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin beta chain VWA domain
- Integrin plexin domain
- cell adhesion molecule binding
- heat shock protein binding
- ICAM-3 receptor
- inserted domain
- Integrin beta tail domain
- Integrin beta cytoplasmic domain
- cytoplasmic domain
- vWFA
- intracellular domain
- plexin/semaphorin/integrin domain
- transmembrane receptor
- extracellular domain
- cargo receptor activity
- protein kinase binding
- NPXF motif
- protein binding
- beta-amyloid binding
- Integrin beta subunits (N-terminal portion of extracellular region)
- antigenic epitope
- EGF-like domain
- binding protein
- CD loop
- integrin binding
- transmembrane domain
- cytosolic tail domain
- Integrin beta epidermal growth factor like domain 1
Pathways
Biological processes and signaling networks where the ITGB2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Agranulocyte Adhesion and Diapedesis
- Caveolar-mediated Endocytosis Signaling
- Clathrin-mediated Endocytosis Signaling
- Complement System
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Ephrin Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- Integrin Signaling
- Macropinocytosis Signaling
- Molecular Mechanisms of Cancer
- MSP-RON Signaling Pathway
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Sertoli Cell-Sertoli Cell Junction Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- squamous cell lung cancer
- lung squamous cell carcinoma
- prostate cancer
- psoriasis
- myocardial infarction
- insulin-dependent diabetes mellitus
- leukocyte adhesion deficiency type I
- diffuse systemic sclerosis
- organismal death
role in cell
- phosphorylation in
- expression in
- invasion by
- migration
- proliferation
- apoptosis
- cell death
- production in
- activation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- Golgi-enriched fraction
- cell surface
- cell borders
- cellular membrane
- immunological synapses
- secretory granule membrane
- tertiary granule membrane
- specific granule membrane
- plasma membrane extracellular face
- uropod
- specific granules
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ITGB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of protein targeting to membrane
- negative regulation of dopamine metabolic process
- cell adhesion
- leukocyte cell-cell adhesion
- beta-amyloid clearance
- regulation of peptidyl-tyrosine phosphorylation
- integrin-mediated signaling pathway
- inflammatory response
- phagocytosis, engulfment
- apoptotic process
- cell-matrix adhesion
- cell-cell signaling
- receptor clustering
- receptor-mediated endocytosis
- positive regulation of neutrophil degranulation
- microglial cell activation
- cell adhesion mediated by integrin
- endodermal cell differentiation
- neutrophil chemotaxis
- positive regulation of prostaglandin-E synthase activity
- heterotypic cell-cell adhesion
- receptor internalization
- cellular response to low-density lipoprotein particle stimulus
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- integrin complex
- plasma membrane
- cell surface
- extracellular vesicular exosome
- focal adhesion
- membrane
- alphaM-beta2 integrin complex
- alphaL-beta2 integrin complex
- tertiary granule membrane
- alphaX-beta2 integrin complex
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- protein kinase binding
- complement component C3b binding
- protein binding
- metal ion binding
- cargo receptor activity
- cell adhesion molecule binding
- integrin binding
- ICAM-3 receptor activity
- beta-amyloid binding