PECAM1 Gene Summary [Human]
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | PECAM1 |
| Official Name | platelet and endothelial cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:8823] |
| Ensembl ID | ENSG00000261371 |
| Bio databases IDs | |
| Aliases | platelet and endothelial cell adhesion molecule 1, CD31 antigen |
| Synonyms | C85791, CD31, CD31/EndoCAM, endoCAM, GPIIA', PECA1, PECAM, PECAM2, platelet and endothelial cell adhesion molecule 1, platelet/endothelial cell adhesion molecule 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PECAM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- protein phosphatase binding
- ectodomain
- Immunoglobulin I-set domain
- protein binding
- homophilic binding domain
- C17orf99 Ig domain
- cytoplasmic domain
- immunoreceptor tyrosine-based inhibition motif
- transmembrane domain
- Immunoglobulin like
- protein homodimerization
- immunoglobulin-like protein domain
- intracellular domain
Pathways
Biological processes and signaling networks where the PECAM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- atopic dermatitis
- rheumatoid arthritis
- myocardial infarction
- anaphylaxis
- essential thrombocythemia
- polyarticular juvenile rheumatoid arthritis
- Alzheimer disease
- metastasis
- pervasive developmental disorder
role in cell
- activation in
- proliferation
- activation
- expression in
- phosphorylation in
- migration
- apoptosis
- growth
- formation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- zipper-like junction
- button-like junction
- cell junction
- ruffle
- Cytoplasm
- cell surface
- cell borders
- Extracellular Space
- cell periphery
- membrane surface
- cellular membrane
- Nucleus
- intercellular junctions
- cell-cell contacts
- secretory granule membrane
- cytosol
- plasma membrane extracellular face
- nucleoplasm
- nucleoli
- alpha granules
- myofibrils
- lateral cell-cell contacts
- membrane rafts
- cell membrane leading edge
- cell-cell adherens junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PECAM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- monocyte extravasation
- signal transduction
- diapedesis
- cell recognition
- cell surface receptor signaling pathway
- homophilic cell adhesion
- establishment of endothelial barrier
- leukocyte cell-cell adhesion
- glomerular endothelium development
- immune response
- positive regulation of protein phosphorylation
- neutrophil extravasation
- tight junction assembly
- phagocytosis
- positive regulation of peptidyl-tyrosine phosphorylation
- maintenance of blood-brain barrier
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular space
- extracellular vesicular exosome
- platelet alpha granule membrane
- cell-cell junction
- membrane raft
- external side of plasma membrane
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- protein homodimerization activity