LINC00461 Gene Summary [Human]
This is an evolutionarily conserved gene that produces alternatively spliced long non-coding RNAs that may be expressed predominantly in the brain and visual cortex. These transcripts may be involved in tumorigenesis, as depletion by siRNA suppressed glioma cell division. Transcripts may also bind to and regulate the activity of miR-411-5p and argonaut 2, thereby altering the expression of genes involved in tumor growth. [provided by RefSeq, Nov 2017]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | LINC00461 |
| Official Name | long intergenic non-protein coding RNA 461 [Source:HGNC Symbol;Acc:HGNC:42810] |
| Ensembl ID | ENSG00000245526 |
| Bio databases IDs | |
| Aliases | long intergenic non-protein coding RNA 461, visual cortex expressed, evolutionary conserved and expressed in neural tissues, neural differentiation initiation of MEF2C expression |
| Synonyms | 2810449C10Rik, C130071C03Rik, ECONEXIN, EyeLinc1, LINC00461, LINC02060, MIR9-2 host gene, NDIME, VISC, Visc-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- non-insulin-dependent diabetes mellitus
- COVID-19
- pervasive developmental disorder
- major depression
- insomnia
- schizophrenia
- Alzheimer disease
- glioma
- glioma formation
role in cell
- expression in
- phosphorylation in
- proliferation
- migration
- G0/G1 phase transition
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LINC00461 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gene silencing by miRNA
Cellular Component
Where in the cell the gene product is active
- RNA-induced silencing complex