Details
| Type | Long Non-Coding RNA |
| Official Symbol | CASC11 |
| Official Name | cancer susceptibility 11 [Source:HGNC Symbol;Acc:HGNC:48939] |
| Ensembl ID | ENSG00000249375 |
| Bio databases IDs | |
| Aliases | cancer susceptibility 11, long intergenic non-protein coding RNA 990, MYC‐modulating lncRNA |
| Synonyms | cancer susceptibility 11, CARLO7, LINC00990, MYMLR, TCONS 00014535 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CASC11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- double-stranded DNA binding
- protein binding activity, bridging
- chromatin binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cancer
- bladder carcinoma
- pancreatic carcinoma
- pancreatic epithelial cancer
- bladder cancer
- sporadic amyotrophic lateral sclerosis
regulated by
- sorafenib
regulates
- SLC7A11
- malondialdehyde
- heavy metal
- RNA polymerase II
- glutathione
- DNA promoter
- DNA endogenous promoter
- lipid reactive oxygen species
role in cell
- expression in
- cell death
- proliferation
- stabilization in
- accumulation in
- depletion in
- extrusion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CASC11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus