SLC7A11 Gene Summary [Human]
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | SLC7A11 |
| Official Name | solute carrier family 7 member 11 [Source:HGNC Symbol;Acc:HGNC:11059] |
| Ensembl ID | ENSG00000151012 |
| Bio databases IDs | |
| Aliases | solute carrier family 7 member 11 |
| Synonyms | 9930009M05RIK, CCBR1, CYSTEINE GLUATAMINE TRANSPORTER, solute carrier family 7 (cationic amino acid transporter, y+ system), member 11, solute carrier family 7 member 11, sut, System xc, xCT |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC7A11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cystine/glutamate antiporter
- amino acid permease
- L-type amino acid transporter
- L-amino acid transporter
- protein binding
- ethanolamine permease
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- cancer
- invasive breast cancer
- hepatocellular carcinoma
- childhood acute lymphoblastic leukemia
- thrombocytopenia
- metastasis
- mucositis
- renal clear cell adenocarcinoma
role in cell
- expression in
- apoptosis
- growth
- phosphorylation in
- proliferation
- cell death
- glycolysis in
- migration
- accumulation in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- apical compartment
- cellular membrane
- brush border
- astrocyte projections
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC7A11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- visual learning
- striatum development
- response to toxin
- amino acid transmembrane transport
- regulation of cellular response to oxidative stress
- lung alveolus development
- regulation of melanin biosynthetic process
- regulation of protein transport
- regulation of glutamate metabolic process
- lens fiber cell differentiation
- platelet aggregation
- regulation of synapse organization
- limb development
- response to nicotine
- response to organic cyclic compound
- regulation of cell proliferation
- ventricular system development
- response to redox state
- glutathione metabolic process
- glutathione transmembrane transport
- cellular response to oxidative stress
- regulation of synaptic transmission
- L-glutamate transport
- L-cystine transport
- adult behavior
- regulation of neutrophil apoptotic process
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- brush border membrane
- apical part of cell
- membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- L-amino acid transmembrane transporter activity
- protein binding
- cystine:glutamate antiporter activity