RHEX Gene Summary [Human]
Enables erythropoietin receptor binding activity. Involved in erythropoietin-mediated signaling pathway and positive regulation of erythrocyte differentiation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RHEX |
| Official Name | regulator of hemoglobinization and erythroid cell expansion [Source:HGNC Symbol;Acc:HGNC:25341] |
| Ensembl ID | ENSG00000263961 |
| Bio databases IDs | |
| Aliases | regulator of hemoglobinization and erythroid cell expansion, regulator of human erythroid cell expansion |
| Synonyms | C1orf186, regulator of haemoglobinization and erythroid cell expansion, regulator of hemoglobinization and erythroid cell expansion |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RHEX often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- erythropoietin receptor binding
- protein binding
- Regulator of human erythroid cell expansion (RHEX)
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RHEX gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythropoietin-mediated signaling pathway
- positive regulation of erythrocyte differentiation
- cellular response to erythropoietin
- erythrocyte maturation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- erythropoietin receptor binding
- protein binding