GET3 Gene Summary [Human]
This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | GET3 |
| Official Name | guided entry of tail-anchored proteins factor 3, ATPase [Source:HGNC Symbol;Acc:HGNC:752] |
| Ensembl ID | ENSG00000198356 |
| Bio databases IDs | |
| Aliases | guided entry of tail-anchored proteins factor 3, ATPase, golgi to ER traffic 3 homolog (S. cerevisiae), transmembrane domain recognition complex, 40kDa |
| Synonyms | 1810048H22Rik, ArsA, ARSA1, ARSA-I, ASNA1, ASNA-I, CMD2H, guided entry of tail-anchored proteins factor 3, ATPase, TRC40 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GET3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transport-energizing ATPase, TRC40/GET3/ArsA family
- arsenite transporter
- protein binding
- ATPase
- P-loop containing Nucleoside Triphosphate Hydrolases
- Anion-transporting ATPase
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- endoplasmic reticulum membrane
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GET3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tail-anchored membrane protein insertion into ER membrane
- protein insertion into ER membrane
- arsenite transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- GET complex
- extracellular vesicular exosome
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- membrane insertase activity
- protein binding
- metal ion binding
- arsenite transmembrane transporter activity