KLF14 Gene Summary [Human]
This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | KLF14 |
| Official Name | Kruppel like factor 14 [Source:HGNC Symbol;Acc:HGNC:23025] |
| Ensembl ID | ENSG00000266265 |
| Bio databases IDs | |
| Aliases | Kruppel like factor 14, KLF transcription factor 14 |
| Synonyms | 5330411L03RIK, BTEB5, KLF transcription factor 14, Kruppel-like transcription factor 14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLF14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- transcription regulator
- double-stranded DNA binding
- chromatin binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- obesity
- neoplasia
- hepatic steatosis
- diabetes mellitus
- nonalcoholic steatohepatitis
regulated by
- 10E,12Z-octadecadienoic acid
- palmitic acid
- oleic acid
- cantharidin
role in cell
- expression in
- production in
- activation in
- accumulation in
- S phase
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLF14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity