Vpreb3 Gene Summary [Mouse]

Predicted to be involved in immune response. Predicted to act upstream of or within negative regulation of immunoglobulin production. Predicted to be located in endoplasmic reticulum. Predicted to be part of immunoglobulin complex. Orthologous to human VPREB3 (V-set pre-B cell surrogate light chain 3). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Vpreb3
Official Name
pre-B lymphocyte gene 3 [Source:MGI Symbol;Acc:MGI:98938]
Ensembl ID
ENSMUSG00000000903
Bio databases IDs NCBI: 22364 Ensembl: ENSMUSG00000000903
Aliases pre-B lymphocyte gene 3
Synonyms 8HS-20, LOC103694871, N27C7-2, V-set pre-B cell surrogate light chain 3
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vpreb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Immunoglobulin V-Type
  • immunoglobulin domain
  • Immunoglobulin like
  • Immunoglobulin V-set domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • insulin-dependent diabetes mellitus
  • mature B-cell neoplasia
  • systemic lupus erythematosus
  • plasma cell neoplasm
  • B cell cancer
  • aldosterone producing adrenocortical adenoma
  • adenoma formation
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Extracellular Space
  • Endoplasmic Reticulum

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Vpreb3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • immune response
  • immunoglobulin production

Cellular Component

Where in the cell the gene product is active
  • extracellular space
  • endoplasmic reticulum
  • extracellular region

Gene-Specific Assays for Results You Can Trust

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