Foxo1 Gene Summary [Mouse]
Enables several functions, including DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to nitric oxide; negative regulation of fat cell differentiation; and negative regulation of insulin secretion. Acts upstream of or within several processes, including insulin receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; and positive regulation of biosynthetic process. Located in cytoplasm. Is active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxo1 |
| Official Name | forkhead box O1 [Source:MGI Symbol;Acc:MGI:1890077] |
| Ensembl ID | ENSMUSG00000044167 |
| Bio databases IDs | |
| Aliases | forkhead box O1 |
| Synonyms | Afxh, FKH1, FKHR, Fkhr1, Forkhead, forkhead box O1, FOXO1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase b phosphorylation site
- transcription regulator
- LXXLL motif
- FH_FOX
- transcription activation domain
- transcription factor binding
- chromatin binding
- cleavage site
- proline rich domain
- Forkhead domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- acidic activation domain
- ubiquitin protein ligase binding
- forkhead box domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- acetylation site
- Akt phosphorylation site
- nuclear export signal
- DNA binding domain
- nucleic acid binding
- beta-catenin binding
- protein phosphatase binding
- Transactivation domain of FOXO protein family
- alpha helix
- protein binding
- sequence-specific DNA binding
- acidic domain
- DNA binding
- phosphorylation site
- FORKHEAD
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- KIX-binding domain of forkhead box O, CR2
- charged domain
- CAD domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Foxo1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adipogenesis pathway
- AMPK Signaling
- Angiopoietin Signaling
- Autophagy
- Cancer Drug Resistance By Drug Efflux
- Docosahexaenoic Acid (DHA) Signaling
- ErbB Signaling
- ErbB2-ErbB3 Signaling
- FXR/RXR Activation
- HER-2 Signaling in Breast Cancer
- IGF-1 Signaling
- IL-3 Signaling
- IL-7 Signaling Pathway
- Insulin Receptor Signaling
- Leptin Signaling in Obesity
- Molecular Mechanisms of Cancer
- Prostate Cancer Signaling
- PTEN Signaling
- PXR/RXR Activation
- Thyroid Cancer Signaling
- VDR/RXR Activation
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- cancer
- neoplasia
- adenoma formation
- diabetes mellitus
- toxic shock syndrome
- Duchenne muscular dystrophy
- leiomyomatosis
role in cell
- expression in
- transcription in
- activity
- differentiation
- invasion
- phosphorylation in
- activation in
- proliferation
- cell death
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smooth muscle cell apoptotic process
- regulation of transcription initiation from RNA polymerase II promoter
- insulin receptor signaling pathway
- negative regulation of insulin secretion
- fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- neuronal stem cell maintenance
- positive regulation of gluconeogenesis
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to insulin stimulus
- negative regulation of transcription, DNA-dependent
- blood vessel development
- positive regulation of transcription, DNA-dependent
- autophagy
- apoptotic process
- energy homeostasis
- regulation of reactive oxygen species metabolic process
- cellular response to nitric oxide
- canonical Wnt receptor signaling pathway
- cellular response to hyperoxia
- regulation of neural precursor cell proliferation
- response to fatty acid
- negative regulation of fat cell differentiation
- positive regulation of protein catabolic process
- protein acetylation
- cellular response to starvation
- response to DNA damage stimulus
- regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of autophagy
- cellular glucose homeostasis
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- temperature homeostasis
- cellular response to oxidative stress
- gene expression
- negative regulation of stress-activated MAPK cascade
- cellular response to cold
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- chromatin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- beta-catenin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- nucleic acid binding
- sequence-specific DNA binding transcription factor activity
- ubiquitin protein ligase binding
- protein binding
- protein phosphatase 2A binding