Klf3 Gene Summary [Mouse]
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Orthologous to human KLF3 (KLF transcription factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klf3 |
| Official Name | Kruppel-like factor 3 (basic) [Source:MGI Symbol;Acc:MGI:1342773] |
| Ensembl ID | ENSMUSG00000029178 |
| Bio databases IDs | |
| Aliases | Kruppel-like factor 3 (basic) |
| Synonyms | 9930027G08RIK, BKLF, Klf3 mapped, KLF transcription factor 3, Kruppel-like transcription factor 3 (basic), Tef-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger DNA binding domain
- CtBP binding domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- transcription repression domain
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
Pathways
Biological processes and signaling networks where the Klf3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillary thyroid cancer
- hepatocellular carcinoma
- epithelial cancer
- juvenile rheumatoid arthritis
- non-small cell lung cancer
- liver cancer
- renal clear cell adenocarcinoma
- cervical cancer
- primary myelofibrosis
- glioblastoma
role in cell
- differentiation
- expression in
- proliferation
- quantity
- development
- transcription in
- signaling in
- hematopoiesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- hemopoiesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity