Sox11 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including camera-type eye development; nervous system development; and regulation of gene expression. Acts upstream of or within skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 9. Orthologous to human SOX11 (SRY-box transcription factor 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sox11 |
| Official Name | SRY (sex determining region Y)-box 11 [Source:MGI Symbol;Acc:MGI:98359] |
| Ensembl ID | ENSMUSG00000063632 |
| Bio databases IDs | |
| Aliases | SRY (sex determining region Y)-box 11 |
| Synonyms | 1110038H03RIK, 6230403H02RIK, CSS9, end1, IDDMOH, MRD27, SRY-box transcription factor 11, SRY (sex determining region Y)-box 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sox11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- high mobility group (HMG)-box domain superfamily
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- transcription factor activity
Pathways
Biological processes and signaling networks where the Sox11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteosarcomagenesis
- tumorigenesis
- edema
- metastasis
- mantle cell lymphoma
- aphakia
- autosomal dominant mental retardation type 27
- craniosynostosis
- glioblastoma
role in cell
- expression in
- growth
- survival
- transactivation in
- apoptosis
- invasion by
- phosphorylation in
- proliferation
- migration
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sox11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hard palate development
- soft palate development
- oligodendrocyte development
- neuroepithelial cell differentiation
- nervous system development
- outflow tract morphogenesis
- positive regulation of neuron differentiation
- embryonic digestive tract morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- lens morphogenesis in camera-type eye
- spinal cord development
- lung morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- sympathetic nervous system development
- negative regulation of lymphocyte proliferation
- skeletal muscle cell differentiation
- kidney development
- negative regulation of transcription regulatory region DNA binding
- closure of optic fissure
- negative regulation of glial cell proliferation
- positive regulation of hippo signaling cascade
- neuron differentiation
- positive regulation of hormone secretion
- brain development
- ventricular septum morphogenesis
- cornea development in camera-type eye
- eyelid development in camera-type eye
- embryonic skeletal system morphogenesis
- positive regulation of ossification
- noradrenergic neuron differentiation
- positive regulation of BMP signaling pathway
- negative regulation of gene expression
- camera-type eye morphogenesis
- positive regulation of stem cell proliferation
- positive regulation of gene expression
- glial cell proliferation
- positive regulation of neurogenesis
- regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of lens epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity