Hmgcll1 Gene Summary [Mouse]
Predicted to enable hydroxymethylglutaryl-CoA lyase activity and metal ion binding activity. Predicted to be involved in L-leucine catabolic process and ketone body biosynthetic process. Predicted to be located in membrane and perinuclear region of cytoplasm. Predicted to be active in cytosol and endoplasmic reticulum. Is expressed in several structures, including blastocyst; extraembryonic component; limb; nervous system; and respiratory system. Orthologous to human HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmgcll1 |
| Official Name | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [Source:MGI Symbol;Acc:MGI:2446108] |
| Ensembl ID | ENSMUSG00000007908 |
| Bio databases IDs | |
| Aliases | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 |
| Synonyms | 3-hydroxy-3-methylglutaryl-CoA lyase like 1, 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1, bA418P12.1, ERCHL, Hmgcli, RGD1565090 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hmgcll1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TIM-like beta/alpha barrel domains
- HMGL-like
- metal ion binding
- enzyme
- hydroxymethylglutaryl-CoA lyase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- Golgi vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hmgcll1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leucine catabolic process
- ketone body biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- membrane
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- hydroxymethylglutaryl-CoA lyase activity