Adamts4 Gene Summary [Mouse]
This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active zinc-dependent aggrecanase enzyme that degrades cartilage. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | Adamts4 |
| Official Name | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 [Source:MGI Symbol;Acc:MGI:1339949] |
| Ensembl ID | ENSMUSG00000006403 |
| Bio databases IDs | |
| Aliases | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 |
| Synonyms | ADAM metallopeptidase with thrombospondin type 1 motif 4, ADAM metallopeptidase with thrombospondin type 1 motif, 4, ADAMS4, ADAMTS-2, ADMP-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adamts4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 domain
- CD36-binding domain
- thrombospondin type 1 repeat
- ADAMTS cysteine-rich domain
- peptidase
- GAG-binding domain
- ADAM-TS Spacer 1
- zinc ion binding
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- furin cleavage consensus sequence
- cysteine rich domain
- Thrombospondin type 1 repeats
- Reprolysin family propeptide
- protease binding
- catalytic domain
- ADAMTS cysteine-rich domain 2
- protein binding
- disintergrin domain
- metallopeptidase
- ZnMc
- spacer domain
- Reprolysin (M12B) family zinc metalloprotease
- pro domain
- Spondin-like TSP1 domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adamts4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- cancer
- Alzheimer disease
- osteoarthritis
- diabetic nephropathy
- rheumatoid arthritis
- Ehlers-Danlos syndrome type VIIC
- Dupuytren contracture
- asthma
- hydronephrosis
role in cell
- quantity
- growth
- number
- morphology
- differentiation
- disassembly
- processing in
- branching
- branching in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- intracellular space
- intracellular storage compartment
- nuclear speckles
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adamts4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- extracellular matrix disassembly
- proteolysis
- extracellular matrix organization
Cellular Component
Where in the cell the gene product is active
- extracellular space
- nuclear speck
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- protease binding
- peptidase activity
- metalloendopeptidase activity
- metallopeptidase activity