Emc10 Gene Summary [Mouse]
Predicted to contribute to membrane insertase activity. Involved in positive regulation of angiogenesis; positive regulation of endothelial cell migration; and positive regulation of endothelial cell proliferation. Located in extracellular region. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human EMC10 (ER membrane protein complex subunit 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Emc10 |
| Official Name | ER membrane protein complex subunit 10 [Source:MGI Symbol;Acc:MGI:1916933] |
| Ensembl ID | ENSMUSG00000008140 |
| Bio databases IDs | |
| Aliases | ER membrane protein complex subunit 10 |
| Synonyms | 2310044H10Rik, 5430410O10Rik, C19orf63, ER membrane protein complex subunit 10, INM02, Mirta22, NEDDFAS |
| Species | Mouse, Mus musculus |
| Orthologies |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- hereditary disorder
- neurodevelopmental disorder with dysmorphic facies and variable seizures
- oligozoospermia
- asthenozoospermia
- hairpin sperm flagellum
regulated by
- D-glucose
- lipopolysaccharide
- topotecan
- decitabine
- AREG
- PLX5622
regulates
- CREB
- enzyme
role in cell
- proliferation
- density
- phosphorylation in
- migration
- abnormal morphology
- capacitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Emc10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein insertion into ER membrane by stop-transfer membrane-anchor sequence
- tail-anchored membrane protein insertion into ER membrane
- angiogenesis
- positive regulation of endothelial cell proliferation
- positive regulation of endothelial cell migration
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- ER membrane protein complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- membrane insertase activity