Sec62 Gene Summary [Mouse]
Predicted to be involved in post-translational protein targeting to membrane, translocation. Predicted to act upstream of or within post-translational protein targeting to endoplasmic reticulum membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and membrane. Orthologous to human SEC62 (SEC62 homolog, preprotein translocation factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sec62 |
| Official Name | SEC62 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1916526] |
| Ensembl ID | ENSMUSG00000027706 |
| Bio databases IDs | |
| Aliases | SEC62 homolog (S. cerevisiae) |
| Synonyms | 3100002M17Rik, Ab2-292, Dtrp1, Ests 92531 at, FLJ32803, HTP1, SEC62 homolog, preprotein translocation, SEC62 homolog, preprotein translocation factor, TLOC1, TP-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sec62 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- rotator cuff injury
- organismal death
- systemic juvenile idiopathic arthritis
role in cell
- expression in
- proliferation
- colony formation
- migration
- invasion by
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- ribosome
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sec62 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cotranslational protein targeting to membrane
- posttranslational protein targeting to membrane, translocation
- posttranslational protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- rough endoplasmic reticulum
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- signaling receptor activity