Clstn3 Gene Summary [Mouse]
Enables cell-cell adhesion mediator activity; enzyme inhibitor activity; and neurexin family protein binding activity. Involved in several processes, including cold-induced thermogenesis; regulation of synapse assembly; and synapse assembly. Acts upstream of or within several processes, including chemical synaptic transmission; positive regulation of protein localization to synapse; and positive regulation of synapse assembly. Located in cell surface; postsynaptic density; and postsynaptic membrane. Part of protein-containing complex. Is active in several cellular components, including GABA-ergic synapse; lipid droplet; and postsynaptic density membrane. Is expressed in brain; central nervous system; cerebellum; dentate gyrus subgranular zone; and testis. Orthologous to human CLSTN3 (calsyntenin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Clstn3 |
| Official Name | calsyntenin 3 [Source:MGI Symbol;Acc:MGI:2178323] |
| Ensembl ID | ENSMUSG00000008153 |
| Bio databases IDs | |
| Aliases | calsyntenin 3 |
| Synonyms | ALC beta, ALC β, calsyntenin 3, CDHR14, Clstn3b, Cs3, Cst-3, CSTN3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clstn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calsyntenin C-terminal
- ectodomain
- cell adhesion molecule binding
- enzyme inhibitor activity
- neurexin binding
- intracellular domain
- Cadherin repeat-like domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- schizophrenia
- hypothermia
- pervasive developmental disorder
role in cell
- differentiation
- growth
- density
- assembly
- differentiation in
- replication in
- synaptic transmission in
- synaptic transmission
- excitatory postsynaptic potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- Endoplasmic Reticulum
- lipid droplets
- endoplasmic reticulum membrane
- postsynaptic membrane
- synaptic membrane
- neurites
- dendrite initial segments
- synapse
- organelle membrane contact site
- perikaryon
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clstn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse assembly
- regulation of cell growth
- positive regulation of synaptic transmission
- homophilic cell adhesion
- positive regulation of synapse assembly
- synaptic transmission, GABAergic
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- dendrite
- postsynaptic membrane
- Golgi membrane
- macromolecular complex
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- neurexin family protein binding