CLSTN3 Gene Summary [Human]
Predicted to enable calcium ion binding activity. Predicted to be involved in positive regulation of synapse assembly and positive regulation of synaptic transmission. Predicted to act upstream of or within several processes, including chemical synaptic transmission; positive regulation of protein localization to synapse; and synapse assembly. Predicted to be located in postsynaptic density. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CLSTN3 |
| Official Name | calsyntenin 3 [Source:HGNC Symbol;Acc:HGNC:18371] |
| Ensembl ID | ENSG00000139182 |
| Bio databases IDs | |
| Aliases | calsyntenin 3, cadherin-related family member 14 |
| Synonyms | ALC beta, ALC β, calsyntenin 3, CDHR14, Clstn3b, Cs3, Cst-3, CSTN3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLSTN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calsyntenin C-terminal
- ectodomain
- cell adhesion molecule binding
- enzyme inhibitor activity
- neurexin binding
- intracellular domain
- Cadherin repeat-like domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- schizophrenia
- hypothermia
- pervasive developmental disorder
role in cell
- differentiation
- growth
- density
- assembly
- differentiation in
- replication in
- synaptic transmission in
- synaptic transmission
- excitatory postsynaptic potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- Endoplasmic Reticulum
- lipid droplets
- endoplasmic reticulum membrane
- postsynaptic membrane
- synaptic membrane
- neurites
- dendrite initial segments
- synapse
- organelle membrane contact site
- perikaryon
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLSTN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse assembly
- regulation of cell growth
- positive regulation of synaptic transmission
- homophilic cell adhesion
- positive regulation of synapse assembly
- synaptic transmission, GABAergic
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- dendrite
- postsynaptic membrane
- Golgi membrane
- macromolecular complex
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- neurexin family protein binding