Prg2 Gene Summary [Mouse]
Predicted to enable carbohydrate binding activity. Predicted to be an extracellular matrix structural constituent conferring compression resistance. Acts upstream of or within defense response to nematode and regulation of cytokine production. Located in collagen-containing extracellular matrix. Is expressed in several structures, including immune system; liver; lung; and male reproductive gland or organ. Orthologous to human PRG2 (proteoglycan 2, pro eosinophil major basic protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prg2 |
| Official Name | proteoglycan 2, bone marrow [Source:MGI Symbol;Acc:MGI:103294] |
| Ensembl ID | ENSMUSG00000027073 |
| Bio databases IDs | |
| Aliases | proteoglycan 2, bone marrow |
| Synonyms | BMPG, EMBP, Major Basic Protein 1, MBP, MBP1, mMBP, mMBP-1, proMBP, Proteoglycan 2, bone marrow, proteoglycan 2, pro eosinophil major basic protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- protein binding
- carbohydrate binding
Pathways
Biological processes and signaling networks where the Prg2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- airway hyperresponsiveness
- stenosis
- colorectal cancer
- colorectal neoplasm
- colorectal neoplasia
- severe preeclampsia
role in cell
- cell death
- growth
- degranulation
- activation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- dense core secretory granule fraction
- ficolin-1-rich granule lumen
- granules
- specific granules
- secretory granules
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to nematode
- immune response
- negative regulation of interleukin-10 production
- negative regulation of macrophage cytokine production
- defense response to bacterium
- positive regulation of interleukin-4 production
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- transport vesicle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- extracellular matrix structural constituent conferring compression resistance
- heparin binding
- carbohydrate binding