Panx3 Gene Summary [Mouse]
Enables calcium channel activity and gap junction hemi-channel activity. Involved in osteoblast differentiation. Located in endoplasmic reticulum membrane; gap junction; and plasma membrane. Is expressed in several structures, including alimentary system; connective tissue; limb; sensory organ; and skeleton. Orthologous to human PANX3 (pannexin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Panx3 |
| Official Name | pannexin 3 [Source:MGI Symbol;Acc:MGI:1918881] |
| Ensembl ID | ENSMUSG00000011118 |
| Bio databases IDs | |
| Aliases | pannexin 3 |
| Synonyms | 3230401P04, 4833413G11Rik, pannexin 3, PX3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Panx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- channel/pore class transporter
- calcium channel
- structural molecule
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endoplasmic reticulum membrane
- gap junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Panx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cation transport
- cell-cell signaling
- osteoblast differentiation
- calcium ion transmembrane transport
- positive regulation of interleukin-1 production
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- gap junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- wide pore channel activity
- calcium channel activity
- gap junction hemi-channel activity
- structural molecule activity