Runx2 Gene Summary [Mouse]
This gene encodes a member of the runt domain-containing family of transcription factors. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Sep 2015]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Runx2 |
| Official Name | runt related transcription factor 2 [Source:MGI Symbol;Acc:MGI:99829] |
| Ensembl ID | ENSMUSG00000039153 |
| Bio databases IDs | |
| Aliases | runt related transcription factor 2 |
| Synonyms | AML3, Cbf, CBFA1, CBF-alpha-1, CBF-α-1, CCD, CCD1, CLCD, LS3, OSF-2, PEA2aA, PEA2-alpha A, PEA2-α A, PEBP2A, PEBP2aA, Pebp2 α A, runt related transcription factor 2, RUNX2C, RUNX2 MRIPV, RUNX family transcription factor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Runx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- Pst domain
- VWRPY domain
- transcription factor binding
- inhibitory domain
- histone deacetylase binding
- chromatin binding
- protein domain specific binding
- runt domain
- protein binding
- sequence-specific DNA binding
- proline tyrosine motif
- DNA binding
- phosphorylation site
- glutamine-alanine rich domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Runx inhibition domain
- double-stranded DNA binding
- transcription factor activity
- nuclear matrix targeting site
Pathways
Biological processes and signaling networks where the Runx2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- osteoarthritis
- primary myelofibrosis
- cleidocranial dysplasia
- cancer
- hypoplasia
- aortic valve calcification
- anaplastic thyroid cancer
- colorectal cancer
role in cell
- growth
- proliferation
- expression in
- quantity
- activation in
- accumulation in
- invasiveness
- migration
- dephosphorylation in
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nuclear matrix
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Runx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of fibroblast growth factor receptor signaling pathway
- ligamentous ossification
- hemopoiesis
- chondrocyte differentiation
- chondrocyte development
- odontogenesis of dentin-containing tooth
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- epithelial cell proliferation
- negative regulation of transcription, DNA-dependent
- stem cell differentiation
- regulation of cell differentiation
- positive regulation of transcription, DNA-dependent
- ossification
- BMP signaling pathway
- stem cell proliferation
- osteoblast differentiation
- positive regulation of epithelial cell proliferation
- embryonic forelimb morphogenesis
- bone mineralization
- neuron differentiation
- SMAD protein signal transduction
- osteoblast fate commitment
- smoothened signaling pathway
- embryonic cranial skeleton morphogenesis
- cell maturation
- regulation of odontogenesis of dentin-containing tooth
- osteoblast development
- negative regulation of smoothened signaling pathway
- regulation of transcription from RNA polymerase II promoter
- T cell differentiation
- positive regulation of gene expression
- positive regulation of stem cell proliferation
- gene expression
- endochondral ossification
- positive regulation of chondrocyte differentiation
- regulation of ossification
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- chromatin DNA binding
- sequence-specific DNA binding transcription factor activity
- protein domain specific binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- bHLH transcription factor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity