Tox4 Gene Summary [Mouse]
Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be part of PTW/PP1 phosphatase complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and hemolymphoid system gland. Orthologous to human TOX4 (TOX high mobility group box family member 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tox4 |
| Official Name | TOX high mobility group box family member 4 [Source:MGI Symbol;Acc:MGI:1915389] |
| Ensembl ID | ENSMUSG00000016831 |
| Bio databases IDs | |
| Aliases | TOX high mobility group box family member 4 |
| Synonyms | 5730589K01Rik, A630040M18, C14orf92, KIAA0737, LCP1, MIG7, RGD708449, TOX high mobility group box family member 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tox4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tox4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- PTW/PP1 phosphatase complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding