Rnf145 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endomembrane system. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human RNF145 (ring finger protein 145). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf145 |
| Official Name | ring finger protein 145 [Source:MGI Symbol;Acc:MGI:1921565] |
| Ensembl ID | ENSMUSG00000019189 |
| Bio databases IDs | |
| Aliases | ring finger protein 145 |
| Synonyms | 3732413I11RIK, FLJ31951, RGD1309561, ring finger protein 145, TMRF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf145 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- TRC8 N-terminal domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Ring finger domain
- RING-like zinc finger
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf145 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endomembrane system
Molecular Function
What the gene product does at the molecular level
- zinc ion binding