Ubc Gene Summary [Mouse]
Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination. Located in myelin sheath. Is expressed in inner ear; jugular lymph sac; oocyte; telencephalon; and trunk unsegmented mesenchyme. Orthologous to human UBC (ubiquitin C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubc |
| Official Name | ubiquitin C [Source:MGI Symbol;Acc:MGI:98889] |
| Ensembl ID | ENSMUSG00000008348 |
| Bio databases IDs | |
| Aliases | ubiquitin C |
| Synonyms | 2700054O04Rik, HMG20, Polyubiquitin, Rps27a, TI-225, Uba52, Ubb, UBIQUITIN C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ubc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- epileptic seizure
role in cell
- proliferation
- degradation in
- growth
- replicative senescence
- cell cycle progression
- destabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endocytic vesicle membrane
- Plasma Membrane
- cytosol
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- endosomal membrane
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- modification-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- mitochondrial outer membrane
- plasma membrane
- nucleoplasm
- endoplasmic reticulum membrane
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- vesicle
- cytosol
- endosome membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- RNA binding
- protein binding
- protein tag