Qrsl1 Gene Summary [Mouse]
Predicted to enable glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Acts upstream of or within mitochondrial translation and regulation of protein stability. Located in mitochondrion. Is expressed in cerebral cortex. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 40. Orthologous to human QRSL1 (glutaminyl-tRNA amidotransferase subunit QRSL1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Qrsl1 |
| Official Name | glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 [Source:MGI Symbol;Acc:MGI:1923813] |
| Ensembl ID | ENSMUSG00000019863 |
| Bio databases IDs | |
| Aliases | glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 |
| Synonyms | 2700038P16RIK, C80053, COXPD40, GatA, glutaminyl-tRNA amidotransferase subunit QRSL1, glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Qrsl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amidase
- glutaminyl-tRNA synthase (glutamine-hydrolysing)
- enzyme
- protein binding
- glutaminyl-tRNA synthase (glutamine-hydrolyzing)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Qrsl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- glutaminyl-tRNAGln biosynthesis via transamidation
- mitochondrial translation
Cellular Component
Where in the cell the gene product is active
- glutamyl-tRNA(Gln) amidotransferase complex
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity