Rhog Gene Summary [Mouse]
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within regulation of ruffle assembly. Predicted to be active in several cellular components, including cytoplasmic vesicle; glutamatergic synapse; and postsynapse. Is expressed in cerebral cortex ventricular layer and meninges. Orthologous to human RHOG (ras homolog family member G). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rhog |
| Official Name | ras homolog family member G [Source:MGI Symbol;Acc:MGI:1928370] |
| Ensembl ID | ENSMUSG00000073982 |
| Bio databases IDs | |
| Aliases | ras homolog family member G |
| Synonyms | 2810426G09RIK, ARHG, ras homolog family member G, Sid10750 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rhog often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- effector domain
- Ras subfamily of RAS small GTPases
- ADP-ribosylation factor family
- CAAX box
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rhog gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Ephrin A Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- GP6 Signaling Pathway
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- NGF Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous-cell carcinoma
- squamous cell cancer
- osteoporosis
- papilloma
- papillomatosis
- Huntington disease
role in cell
- apoptosis
- proliferation
- phosphorylation in
- activation in
- migration
- function
- aggregation
- formation
- formation in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cell surface
- perinuclear region
- postsynaptic region
- Nucleus
- Plasma Membrane
- secretory granule membrane
- cytosol
- endoplasmic reticulum membrane
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rhog gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- regulation of cell shape
- positive regulation of cell proliferation
- establishment or maintenance of cell polarity
- actin filament organization
- regulation of ruffle assembly
- Rho protein signal transduction
- cell chemotaxis
- cortical cytoskeleton organization
- regulation of actin cytoskeleton organization
- positive regulation of transcription, DNA-dependent
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- secretory granule membrane
- cytoskeleton
- extracellular vesicular exosome
- focal adhesion
- cytoplasmic vesicle
- cytosol
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- protein binding
- GTPase activity