Lpin1 Gene Summary [Mouse]
Enables several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate phosphatase activity. Involved in several processes, including mitochondrial fission; positive regulation of metabolic process; and triglyceride metabolic process. Acts upstream of or within several processes, including cellular response to insulin stimulus; regulation of fat cell differentiation; and ruffle organization. Located in endoplasmic reticulum; mitochondrial outer membrane; and nuclear membrane. Part of transcription regulator complex. Is active in endoplasmic reticulum membrane. Is expressed in liver; nervous system; olfactory epithelium; and tooth. Used to study lipodystrophy. Orthologous to human LPIN1 (lipin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lpin1 |
| Official Name | lipin 1 [Source:MGI Symbol;Acc:MGI:1891340] |
| Ensembl ID | ENSMUSG00000020593 |
| Bio databases IDs | |
| Aliases | lipin 1 |
| Synonyms | fld, LIPIN, Lipin-1, PAP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lpin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-activator
- peroxisome proliferator activated receptor binding
- Lipin/Ned1/Smp2 multi-domain protein middle domain
- phosphatidate phosphatase
- phosphatase
- transcription factor binding
- histone deacetylase binding
- protein binding
- LNS2 (Lipin/Ned1/Smp2)
- lipin, N-terminal conserved region
- Haloacid Dehalogenase-like Hydrolases
Pathways
Biological processes and signaling networks where the Lpin1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- obesity
- insulin resistance
- hepatic steatosis
- allergic rhinitis
- steatohepatitis
- autosomal recessive acute recurrent myoglobinuria
- myopathy with ongoing muscle fiber necrosis and regeneration
- demyelination
phenotypes
- abnormal PNS glial cell morphology
- abnormal Schwann cell morphology
- abnormal action potential
- abnormal aorta morphology
- abnormal axon morphology
- abnormal brown adipose tissue morphology
- abnormal brown adipose tissue physiology
- abnormal cholesterol homeostasis
- abnormal enzyme/coenzyme activity
- abnormal enzyme/coenzyme level
- abnormal epididymal fat pad morphology
- abnormal fat cell morphology
- abnormal fat pad morphology
- abnormal gait
- abnormal gluconeogenesis
- abnormal glucose homeostasis
- abnormal hair growth
- abnormal lipid homeostasis
- abnormal lipid level
- abnormal metabolism
- abnormal motor coordination/ balance
- abnormal myelin sheath morphology
- abnormal myelination
- abnormal phospholipid level
- abnormal respiratory quotient
- abnormal sciatic nerve morphology
- abnormal spermatocyte morphology
- abnormal triglyceride level
- abnormal white adipose tissue physiology
- axon degeneration
- decreased body fat mass
- decreased body size
- decreased body weight
- decreased brown adipose tissue mass
- decreased brown fat cell lipid droplet size
- decreased circulating LDL cholesterol level
- decreased circulating VLDL cholesterol level
- decreased circulating leptin level
- decreased epididymal fat pad weight
- decreased fatty acid level
- decreased hormone-sensitive lipase activity
- decreased inguinal fat pad weight
- decreased insulin secretion
- decreased interscapular fat pad weight
- decreased joint mobility
- decreased lean body mass
- decreased lipoprotein lipase activity
- decreased nerve conduction velocity
- decreased survivor rate
- decreased triglyceride level
- decreased triglyceride lipase activity
- decreased white adipose tissue mass
- decreased white fat cell lipid droplet size
- delayed female fertility
- demyelination
- disheveled coat
- distended abdomen
- enlarged liver
- female infertility
- hepatic steatosis
- impaired glucose tolerance
- impaired limb coordination
- increased cholesterol level
- increased circulating HDL cholesterol level
- increased circulating VLDL triglyceride level
- increased circulating glucose level
- increased circulating insulin level
- increased circulating triglyceride level
- increased fatty acid level
- increased glycogen level
- increased grip strength
- increased liver triglyceride level
- increased triglyceride level
- insulin resistance
- lethality at weaning incomplete penetrance
- limb grasping
- male infertility
- pale liver
- peripheral nervous system degeneration
- postnatal lethality incomplete penetrance
- premature death
- retarded hair growth
- ruffled hair
- tremors
role in cell
- production in
- expression in
- activation in
- proliferation
- phosphorylation in
- quantity
- accumulation in
- apoptosis
- transcription in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microsomal fraction
- soluble fraction
- Cytoplasm
- Endoplasmic Reticulum
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- nucleoplasm
- nuclear envelope
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lpin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- fatty acid catabolic process
- mitotic nuclear envelope disassembly
- triglyceride biosynthetic process
- phosphatidylethanolamine metabolic process
- positive regulation of DNA replication
- organ regeneration
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of myelination
- triglyceride mobilization
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- nucleus
- nuclear membrane
- cytoplasm
- cytosol
- endoplasmic reticulum
- mitochondrial outer membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidate phosphatase activity
- protein binding
- transcription coactivator activity