Adrb2 Gene Summary [Mouse]
This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 adrenergic receptor which is activated by catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]
Details
| Type | Protein Coding |
| Official Symbol | Adrb2 |
| Official Name | adrenergic receptor, beta 2 [Source:MGI Symbol;Acc:MGI:87938] |
| Ensembl ID | ENSMUSG00000045730 |
| Bio databases IDs | |
| Aliases | adrenergic receptor, beta 2 |
| Synonyms | ADRB2R, ADR-beta2, ADRBR, Adrenergic Receptor Beta 2, adrenergic receptor, beta 2, Adrenergic Receptor β 2, adrenergic receptor, β 2, adrenoceptor beta 2, adrenoceptor β 2, ADR-β2, ARB2, B2AR, Badm, BAR, Beta2 Adrenergic Receptor, Beta-2 adrenoceptor, BETA2AR, Beta-2 receptor, Beta-adrenergic receptor 2a, Gpcr7, β 2-adrenergic receptor, β-2 adrenoceptor, β(2)AR, β2-AR, β-2 receptor, β-adrenergic receptor 2a |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adrb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- identical protein binding
- proline rich domain
- seven-transmembrane G protein-coupled receptor superfamily
- cytoplasmic domain
- ligand-binding domain
- intracellular domain
- extracellular loop
- tail domain
- Pka phosphorylation site
- G-protein binding domain
- G-protein coupled receptor
- hormone binding
- palmitoylation site
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- (E/D)RY motif
- Akt phosphorylation site
- protein phosphatase binding
- potassium channel regulator
- enzyme binding
- helical domain
- protein binding
- receptor binding
- beta-amyloid binding
- ionotropic glutamate receptor binding
- PDZ-domain binding
- phosphorylation site
- dileucine internalization motif
- beta2-adrenergic receptor
- binding protein
- adenylate cyclase binding
- cytoplasmic loop
- transmembrane domain
- protein homodimerization
- 7 transmembrane receptor (rhodopsin family)
- cytosolic tail domain
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Adrb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Breast Cancer Regulation by Stathmin1
- Cardiac Hypertrophy Signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- G-Protein Coupled Receptor Signaling
- Glucocorticoid Receptor Signaling
- Gαs Signaling
- Myc Mediated Apoptosis Signaling
- Phagosome Formation
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- fibrosis
- neoplasia
- non-insulin-dependent diabetes mellitus
- metastatic esophageal cancer
- anxiety disorder
- depressive disorder
- major depression
- chemotherapy sickness
- headache
role in cell
- expression in
- internalization by
- production in
- activation in
- internalization in
- phosphorylation in
- degradation in
- signaling in
- migration
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- caveolae fraction
- membrane fraction
- glutaminergic synapse
- microtubule cytoskeleton
- endocytic vesicle membrane
- Cytoplasm
- cilia
- cell surface
- cell borders
- cellular membrane
- Nucleus
- basal bodies
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- cytoplasmic bridges
- apical membrane
- postsynaptic membrane
- caveolae
- endosomal membrane
- dendritic spines
- synapse
- sarcolemma
- secretory granules
- membrane rafts
- mitotic spindle
- perikaryon
- axons
- dendrites
- axosomatic synapses
- axodendritic synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adrb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- activation of transmembrane receptor protein tyrosine kinase activity
- negative regulation of multicellular organism growth
- positive regulation of cAMP-dependent protein kinase activity
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of G-protein coupled receptor protein signaling pathway
- diet induced thermogenesis
- negative regulation of smooth muscle contraction
- vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
- positive regulation of protein kinase A signaling cascade
- response to cold
- brown fat cell differentiation
- smooth muscle contraction
- bone resorption
- adrenergic receptor signaling pathway
- positive regulation of bone mineralization
- endosome to lysosome transport
- cell surface receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- positive regulation of MAPK cascade
- receptor-mediated endocytosis
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
- heat generation
- regulation of sodium ion transport
- adenylate cyclase-activating adrenergic receptor signaling pathway
- positive regulation of protein serine/threonine kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- endosome
- clathrin-coated endocytic vesicle membrane
- membrane
- receptor complex
- Golgi apparatus
- endosome membrane
- plasma membrane
- apical plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- beta2-adrenergic receptor activity
- identical protein binding
- protein binding
- protein homodimerization activity
- adenylate cyclase binding
- norepinephrine binding
- potassium channel regulator activity
- beta-amyloid binding