Mettl3 Gene Summary [Mouse]
Enables mRNA m(6)A methyltransferase activity. Involved in several processes, including RNA metabolic process; forebrain radial glial cell differentiation; and mRNA destabilization. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in brain; genitourinary system; hindlimb; intestine; and liver. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mettl3 |
| Official Name | methyltransferase like 3 [Source:MGI Symbol;Acc:MGI:1927165] |
| Ensembl ID | ENSMUSG00000022160 |
| Bio databases IDs | |
| Aliases | methyltransferase like 3 |
| Synonyms | 2310024F18Rik, hMETTL3, IME4, M6A, methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit, MT-A70, Spo8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mettl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MT-A70
- mRNA (N6-adenosine)-methyltransferase
- binding protein
- mRNA binding
- RNA methyltransferase
- enzyme
- protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- neoplasia
- cancer
- epithelial cancer
- leukemia
- breast cancer
- liver cancer
- colorectal cancer
- prostate cancer
- tumorigenesis
role in cell
- cell death
- expression in
- apoptosis
- growth
- phosphorylation in
- proliferation
- colony formation
- degradation in
- damage in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Golgi Apparatus
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mettl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell maintenance
- mRNA destabilization
- positive regulation of translation
- primary miRNA processing
- spermatogenesis
- negative regulation of type I interferon-mediated signaling pathway
- dosage compensation by inactivation of X chromosome
- mRNA processing
- negative regulation of Notch signaling pathway
- circadian rhythm
- response to DNA damage stimulus
- forebrain radial glial cell differentiation
- nuclear mRNA splicing, via spliceosome
- regulation of T cell differentiation
- regulation of meiotic cell cycle
- RNA methylation
- oogenesis
- gliogenesis
- innate immune response
- cellular response to UV
- mRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- nuclear speck
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA methyltransferase activity
- protein binding
- mRNA (N6-adenosine)-methyltransferase activity
- protein heterodimerization activity
- mRNA binding
- mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity