Slmap Gene Summary [Mouse]
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; regulation of membrane depolarization during cardiac muscle cell action potential; and regulation of voltage-gated sodium channel activity. Located in membrane. Is expressed in heart. Orthologous to human SLMAP (sarcolemma associated protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slmap |
| Official Name | sarcolemma associated protein [Source:MGI Symbol;Acc:MGI:1933549] |
| Ensembl ID | ENSMUSG00000021870 |
| Bio databases IDs | |
| Aliases | sarcolemma associated protein |
| Synonyms | D330001L02Rik, Miranda, mKIAA1601, Sarcol assoc prot, Sarcolemma Associated, sarcolemma associated protein, SLAP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slmap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, primarily archaeal type
- Ciliary protein causing Leber congenital amaurosis disease
- Ezrin/radixin/moesin, alpha-helical domain
- CCDC144C protein coiled-coil region
- Hyaluronan mediated motility receptor N-terminal
- Synaptonemal complex protein 1 (SCP-1)
- protein binding activity, bridging
- enzyme binding
- helix-rich Mycoplasma protein
- Forkhead associated domain
- protein binding
- forkhead associated (FHA) domain superfamily
- Tropomyosin
- RIM-binding protein of the cytomatrix active zone
- CC1_SLMAP-like
- FHA domain
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- non-insulin-dependent diabetes mellitus
- Brugada syndrome
- infantile hypertrophic pyloric stenosis
- late-onset Alzheimer disease
- chronic obstructive pulmonary disease
regulates
- Na+
role in cell
- growth
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- smooth endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slmap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of hippo signaling cascade
- muscle contraction
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Z disc
- centrosome
- mitochondrial membrane
- cytoplasm
- smooth endoplasmic reticulum
- sarcolemma
- M band
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding, bridging