Zfpm1 Gene Summary [Mouse]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in embryonic hemopoiesis; heart development; and negative regulation of mast cell differentiation. Acts upstream of or within several processes, including myeloid cell differentiation; regulation of chemokine production; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and heart. Orthologous to human ZFPM1 (zinc finger protein, FOG family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfpm1 |
| Official Name | zinc finger protein, multitype 1 [Source:MGI Symbol;Acc:MGI:1095400] |
| Ensembl ID | ENSMUSG00000049577 |
| Bio databases IDs | |
| Aliases | zinc finger protein, multitype 1 |
| Synonyms | FOG, FOG1, LOC100365064, ZC2HC11A, zinc finger protein, FOG family member 1, zinc finger protein, multitype 1, ZNF408, ZNF89A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfpm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CtBP binding domain
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- transcription co-repressor
- transcription factor binding
- protein binding
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- coronary artery disease
- non-insulin-dependent diabetes mellitus
- thrombocytopenia
- kidney stones
- anemia
- testicular germ cell tumor
- germ cell neoplasia
- urolithiasis
- granulocytosis
role in cell
- expression in
- formation
- binding in
- differentiation
- phosphorylation in
- development
- aggregation
- number
- erythropoiesis
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfpm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic hemopoiesis
- mitral valve formation
- outflow tract morphogenesis
- tricuspid valve formation
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of protein binding
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- positive regulation of interferon-gamma production
- megakaryocyte development
- platelet formation
- regulation of chemokine production
- cardiac muscle tissue morphogenesis
- negative regulation of mast cell differentiation
- atrioventricular valve morphogenesis
- definitive erythrocyte differentiation
- T-helper cell lineage commitment
- primitive erythrocyte differentiation
- ventricular septum morphogenesis
- atrial septum morphogenesis
- megakaryocyte differentiation
- negative regulation of interleukin-4 production
- erythrocyte differentiation
- regulation of definitive erythrocyte differentiation
- granulocyte differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- transcriptional repressor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- transcription corepressor activity