Gucy1b2 Gene Summary [Mouse]
Predicted to enable guanylate cyclase activity and nitric oxide binding activity. Predicted to be involved in cGMP-mediated signaling and response to oxygen levels. Predicted to be part of guanylate cyclase complex, soluble. Is expressed in spinal cord. Orthologous to human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gucy1b2 |
| Official Name | guanylate cyclase 1, soluble, beta 2 [Source:MGI Symbol;Acc:MGI:2660873] |
| Ensembl ID | ENSMUSG00000021933 |
| Bio databases IDs | |
| Aliases | guanylate cyclase 1, soluble, beta 2 |
| Synonyms | B930025B03, GC-SB2, guanylate cyclase 1, soluble, beta 2, guanylate cyclase 1 soluble subunit beta 2, guanylate cyclase 1 soluble subunit β 2, guanylate cyclase 1, soluble, β 2, Gucy1b2a, Gucy1b2b, SGC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gucy1b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Heme NO binding associated
- Haem-NO-binding
- binding protein
- guanylate cyclase
- Class III nucleotidyl cyclases
- enzyme
- Adenylyl- / guanylyl cyclase, catalytic domain
Pathways
Biological processes and signaling networks where the Gucy1b2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Antiproliferative Role of Somatostatin Receptor 2
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- eNOS Signaling
- Gap Junction Signaling
- Inhibition of Angiogenesis by TSP1
- Nitric Oxide Signaling in the Cardiovascular System
- Phototransduction Pathway
- Relaxin Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Sperm Motility
- Synaptic Long Term Depression
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
regulated by
- methamphetamine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol