Mtnr1b Gene Summary [Mouse]
Predicted to enable melatonin receptor activity. Predicted to be involved in several processes, including negative regulation of cell communication; positive regulation of circadian sleep/wake cycle, non-REM sleep; and regulation of transmission of nerve impulse. Predicted to act upstream of or within circadian rhythm. Predicted to be active in plasma membrane. Is expressed in alimentary system; central nervous system; eye; and reproductive system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (melatonin receptor 1B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Mtnr1b |
| Official Name | melatonin receptor 1B [Source:MGI Symbol;Acc:MGI:2181726] |
| Ensembl ID | ENSMUSG00000050901 |
| Bio databases IDs | |
| Aliases | melatonin receptor 1B |
| Synonyms | FGQTL2, Mel1b, MEL-1B-R, melatonin receptor 1B, MT2, MT2 receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtnr1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- melatonin receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Mtnr1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Parkinson disease
- Alzheimer disease
- fatigue
- major depression
- insomnia
- susceptibility to type 2 diabetes mellitus
- traumatic brain injury
- attention deficit hyperactivity disorder
- cognitive impairment
role in cell
- expression in
- apoptosis
- plasticity
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtnr1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- negative regulation of vasoconstriction
- synaptic transmission
- reduction of cytosolic calcium ion concentration
- negative regulation of insulin secretion
- negative regulation of neuron apoptotic process
- positive regulation of circadian sleep/wake cycle, non-REM sleep
- regulation of insulin secretion
- negative regulation of transmission of nerve impulse
- positive regulation of transmission of nerve impulse
- camera-type eye development
- glucose homeostasis
- negative regulation of cGMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- melatonin receptor activity