Zmym2 Gene Summary [Mouse]
This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transforming growth factor-beta signaling as a Smad binding protein. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | Zmym2 |
| Official Name | zinc finger, MYM-type 2 [Source:MGI Symbol;Acc:MGI:1923257] |
| Ensembl ID | ENSMUSG00000021945 |
| Bio databases IDs | |
| Aliases | zinc finger, MYM-type 2 |
| Synonyms | 5830413P05Rik, FIM, MYM, NECRC, RAMP, SCLL, Zfp198, zinc finger, MYM-type 2, zinc finger MYM-type containing 2, ZINC FINGER protein 198, ZNF198 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zmym2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Domain of unknown function (DUF3504)
- enzyme binding
- protein binding
- zinc finger domain
- proline rich domain
- Ribosomal_L24e_L24
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- neurodevelopmental-craniofacial syndrome with variable renal and cardiac abnormalities
- hereditary disorder
- congenital anomalies of kidney and urinary tract
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- neurodevelopmental disorder
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
role in cell
- formation
- proliferation
- activation in
- growth
- differentiation
- apoptosis
- cell cycle progression
- cell death
- survival
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nucleoli
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zmym2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- ubiquitin conjugating enzyme binding
- protein binding