Plekha4 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in positive regulation of Wnt signaling pathway, planar cell polarity pathway and positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in foregut; naris; nervous system; respiratory system cartilage; and turbinate bone primordium. Orthologous to human PLEKHA4 (pleckstrin homology domain containing A4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekha4 |
| Official Name | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 [Source:MGI Symbol;Acc:MGI:1916467] |
| Ensembl ID | ENSMUSG00000040428 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 |
| Synonyms | 2410005C22Rik, PEPP1, pleckstrin homology domain containing A4, pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekha4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- phosphatidylinositol-4,5-bisphosphate binding
- PH domain
- protein binding
- Pleckstrin homology-like domain
- identical protein binding
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the Plekha4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytoplasmic face of plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekha4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- positive regulation of canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- extrinsic to internal side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding
- phosphatidylinositol-3,4-bisphosphate binding