Chrna2 Gene Summary [Mouse]
Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity and quaternary ammonium group binding activity. Predicted to contribute to acetylcholine receptor activity and heterocyclic compound binding activity. Acts upstream of or within regulation of synaptic plasticity. Located in cell periphery. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 4 and benign familial infantile seizures 6. Orthologous to human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrna2 |
| Official Name | cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) [Source:MGI Symbol;Acc:MGI:87886] |
| Ensembl ID | ENSMUSG00000022041 |
| Bio databases IDs | |
| Aliases | cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) |
| Synonyms | ACHR, Acra-2, cholinergic receptor nicotinic alpha 2 subunit, cholinergic receptor nicotinic α 2 subunit, nAChR alpha2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chrna2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- acetylcholine receptor
- neurotransmitter receptor
- binding protein
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the Chrna2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- carbamylcholine
- doxacurium
- pipecuronium
- isoflurane
- ABT-089
- pancuronium
- ABT 418
- enflurane
- D-tubocurarine
- mecamylamine
disease
- non-insulin-dependent diabetes mellitus
- nicotine withdrawal syndrome
- Alzheimer disease
- nicotine dependence
- gallbladder disease
- pain
- traumatic brain injury
- postoperative delirium
- bladder cancer
- HIV infection
role in cell
- long-term potentiation
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell periphery
- cellular membrane
- cytoplasmic bridges
- nucleoplasm
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chrna2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- ion transport
- regulation of excitatory postsynaptic membrane potential
- signal transduction
- ion transmembrane transport
- response to nicotine
- membrane depolarization
- cellular response to nicotine
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- postsynaptic membrane
- membrane
- acetylcholine-gated channel complex
- synapse
- neuron projection
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- acetylcholine receptor activity
- acetylcholine-gated cation channel activity
- quaternary ammonium group binding