Chrna2 Gene Summary [Rat]
Enables acetylcholine-gated monoatomic cation-selective channel activity; heterocyclic compound binding activity; and quaternary ammonium group binding activity. Involved in cellular response to nicotine; modulation of inhibitory postsynaptic potential; and response to acetylcholine. Located in neuron projection cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 4 and benign familial infantile seizures 6. Orthologous to human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrna2 |
| Official Name | cholinergic receptor nicotinic alpha 2 subunit [Source:RGD Symbol;Acc:621533] |
| Ensembl ID | ENSRNOG00000017424 |
| Bio databases IDs | |
| Aliases | cholinergic receptor nicotinic alpha 2 subunit |
| Synonyms | ACHR, Acra-2, cholinergic receptor nicotinic alpha 2 subunit, cholinergic receptor nicotinic α 2 subunit, nAChR alpha2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chrna2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- acetylcholine receptor
- neurotransmitter receptor
- binding protein
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the Chrna2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- carbamylcholine
- doxacurium
- pipecuronium
- isoflurane
- ABT-089
- pancuronium
- ABT 418
- enflurane
- D-tubocurarine
- mecamylamine
disease
- non-insulin-dependent diabetes mellitus
- nicotine withdrawal syndrome
- Alzheimer disease
- nicotine dependence
- gallbladder disease
- pain
- traumatic brain injury
- postoperative delirium
- bladder cancer
- HIV infection
role in cell
- long-term potentiation
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell periphery
- cellular membrane
- cytoplasmic bridges
- nucleoplasm
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chrna2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- ion transport
- regulation of excitatory postsynaptic membrane potential
- signal transduction
- ion transmembrane transport
- response to nicotine
- membrane depolarization
- cellular response to nicotine
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- postsynaptic membrane
- membrane
- acetylcholine-gated channel complex
- synapse
- neuron projection
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- acetylcholine receptor activity
- acetylcholine-gated cation channel activity
- quaternary ammonium group binding