Stat5b Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in cellular response to growth factor stimulus; growth hormone receptor signaling pathway via JAK-STAT; and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on taurine metabolic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of defense response; and positive regulation of lymphocyte activation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; growth hormone insensitivity syndrome with immune dysregulation 1; and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stat5b |
| Official Name | signal transducer and activator of transcription 5B [Source:MGI Symbol;Acc:MGI:103035] |
| Ensembl ID | ENSMUSG00000020919 |
| Bio databases IDs | |
| Aliases | signal transducer and activator of transcription 5B |
| Synonyms | GHISID2, LOC107984978, signal transducer and activator of transcription 5B, STAT5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stat5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- transcription regulator
- STAT protein, DNA binding domain
- transcription activation domain
- transcription factor binding
- chromatin binding
- coiled-coil domain
- identical protein binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- STAT_CCD
- Src homology 2 (SH2) domain
- STAT protein, protein interaction domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- ligand-dependent nuclear receptor interactor
- DNA binding domain
- nucleic acid binding
- linker domain
- protein binding
- sequence-specific DNA binding
- STAT protein, all-alpha domain
- DNA binding
- phosphorylation site
- double-stranded DNA binding
- protein homodimerization
- transcription factor activity
- DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
Pathways
Biological processes and signaling networks where the Stat5b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Angiopoietin Signaling
- ErbB2-ErbB3 Signaling
- Estrogen-Dependent Breast Cancer Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- Growth Hormone Signaling
- IL-2 Signaling
- IL-22 Signaling
- IL-3 Signaling
- IL-7 Signaling Pathway
- IL-9 Signaling
- JAK/Stat Signaling
- Oncostatin M Signaling
- Prolactin Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of Tissue Factor in Cancer
- Th2 Pathway
- Thrombopoietin Signaling
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- T acute lymphoblastic leukemia
- immunodeficiency
- diabetes mellitus
- head and neck squamous cell cancer
- neoplasia
- hepatosplenic T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- splenic cancer
role in cell
- expression in
- phosphorylation in
- cell viability
- binding in
- apoptosis
- growth
- activation in
- formation
- production in
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- microtubules
- cytosol
- nucleoplasm
- chromatin
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stat5b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- transcription from RNA polymerase II promoter
- negative regulation of erythrocyte differentiation
- positive regulation of erythrocyte differentiation
- JAK-STAT cascade
- T cell homeostasis
- natural killer cell proliferation
- activated T cell proliferation
- JAK-STAT cascade involved in growth hormone signaling pathway
- B cell differentiation
- positive regulation of inflammatory response
- development of secondary female sexual characteristics
- natural killer cell mediated cytotoxicity
- development of secondary male sexual characteristics
- response to peptide hormone stimulus
- positive regulation of activated T cell proliferation
- positive regulation of mitotic cell cycle
- positive regulation of B cell differentiation
- luteinization
- regulation of epithelial cell differentiation
- erythrocyte differentiation
- response to interleukin-15
- cellular response to growth factor stimulus
- response to interleukin-4
- cellular response to epidermal growth factor stimulus
- response to estradiol stimulus
- cellular response to hormone stimulus
- regulation of multicellular organism growth
- positive regulation of gamma-delta T cell differentiation
- lactation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of multicellular organism growth
- mitotic cell cycle
- positive regulation of natural killer cell differentiation
- cytokine-mediated signaling pathway
- Peyer's patch development
- response to interleukin-2
- positive regulation of interleukin-2 production
- progesterone metabolic process
- negative regulation of myeloid cell apoptotic process
- T cell differentiation in thymus
- female pregnancy
- defense response
- regulation of cell proliferation
- positive regulation of natural killer cell mediated cytotoxicity
- regulation of transcription from RNA polymerase II promoter
- positive regulation of natural killer cell proliferation
- gamma-delta T cell differentiation
- natural killer cell differentiation
- taurine metabolic process
- regulation of steroid metabolic process
- myeloid cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein homodimerization activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- protein dimerization activity
- chromatin binding
- glucocorticoid receptor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity