Gzme Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be located in cytolytic granule. Predicted to be active in cytoplasm and extracellular space. Is expressed in extraembryonic component; placenta; spongiotrophoblast; and trophoblast giant cell. Orthologous to several human genes including GZMB (granzyme B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gzme |
| Official Name | granzyme E [Source:MGI Symbol;Acc:MGI:109265] |
| Ensembl ID | ENSMUSG00000022156 |
| Bio databases IDs | |
| Aliases | granzyme E |
| Synonyms | CCP3, CCP4, CCP5, Ctla-5, Ctla-6, Ctla-7, granzyme D, granzyme E, granzyme F, granzyme G, Grz d, Grz e, Grz f, Grz g, Gzmd, Gzme, Gzmg, LOC100910060, MCSP-2, MCSP-3, Rnkp7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gzme often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- peptidase
- Trypsin-like peptidase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- accumulation in
- cell death
- generation in
- damage in
- damage
- vacuolation in
- condensation
- antibody-dependent cell-mediated cytotoxicity
- swelling in
- condensation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
- granules