Eed Gene Summary [Mouse]
Enables chromatin binding activity; enzyme activator activity; and methylated histone binding activity. Involved in facultative heterochromatin formation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of adaxial/abaxial pattern formation; and regulation of gene expression. Located in pronucleus and sex chromatin. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including branchial arch; central nervous system; early embryo; embryo mesenchyme; and genitourinary system. Orthologous to human EED (embryonic ectoderm development). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eed |
| Official Name | embryonic ectoderm development [Source:MGI Symbol;Acc:MGI:95286] |
| Ensembl ID | ENSMUSG00000030619 |
| Bio databases IDs | |
| Aliases | embryonic ectoderm development |
| Synonyms | COGIS, embryonic ectoderm development, HEED, l(7)5Rn, l7Rn5, lusk, WAIT1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eed often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- WD40 repeats
- sphingomyelin phosphodiesterase activator
- nuclear localization sequence
- WD domain, G-beta repeat
- transcription factor binding
- WD40
- chromatin binding
- protein binding
- enzyme activator activity
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- organismal death
- thymus cancer
- lymphoid cancer
- mediastinal cancer
- lymphatic neoplasia
- lymphomagenesis
- thoracic cancer
- hematologic cancer
- hematological neoplasia
role in cell
- expression in
- proliferation
- activation in
- number
- differentiation
- development
- invasion by
- derepression in
- trimethylation in
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- insoluble fractions
- Plasma Membrane
- cytosol
- nucleoplasm
- sex chromatin
- pronucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eed gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- heterochromatin assembly
- spinal cord development
Cellular Component
Where in the cell the gene product is active
- nucleus
- ESC/E(Z) complex
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- identical protein binding
- protein binding
- nucleosome binding
- histone methyltransferase activity
- enzyme activator activity