Wdtc1 Gene Summary [Mouse]
Enables enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Acts upstream of or within several processes, including cellular response to insulin stimulus; glucose metabolic process; and negative regulation of biosynthetic process. Located in cytosol and nucleus. Is expressed in cerebral cortex; heart ventricle; lung; and pancreas. Orthologous to human WDTC1 (WD and tetratricopeptide repeats 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdtc1 |
| Official Name | WD and tetratricopeptide repeats 1 [Source:MGI Symbol;Acc:MGI:2685541] |
| Ensembl ID | ENSMUSG00000037622 |
| Bio databases IDs | |
| Aliases | WD and tetratricopeptide repeats 1 |
| Synonyms | adipose, ADP, DCAF9, Gm695, WD and tetratricopeptide repeats 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdtc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- TPR repeat
- WD40 repeats
- Tetratricopeptide repeats
- enzyme inhibitor activity
- WD domain, G-beta repeat
- histone deacetylase binding
- protein binding
- tetratricopeptide repeat
- Anaphase-promoting complex, cyclosome, subunit 3
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdtc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cellular chemical homeostasis
- negative regulation of fatty acid biosynthetic process
- cellular response to insulin stimulus
- multicellular organism growth
- in utero embryonic development
- regulation of cell size
- glucose metabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding
- histone binding
- enzyme inhibitor activity